Can the Tasmanian Tiger Come Back from Extinction? – GWC Mag

In an attempt to reverse extinction, scientists have embarked on an ambitious project to bring back the Tasmanian Tiger, which vanished from the wild in 1936. Spearheading this revolutionary effort is Andrew Pask, a marsupial evolutionary biologist professor at the University of Melbourne, who heads the Thylacine Integrated Genetic Restoration Research (TIGRR) project.

The catalyst for this venture was a generous $5 million grant from the Wilson Family Trust, spurred by the interest of Russell Wilson, the trust’s head, who became captivated by Pask’s research after watching his YouTube videos. Pask’s journey toward de-extinction began with a meticulous examination of intact museum specimens, revealing surprisingly well-preserved genomes. His work culminated in 2005 when he successfully revived the function of a single Tasmanian tiger gene in a mouse embryo, marking the first milestone in genetic restoration.

Speaking about his pioneering efforts, Pask emphasized his commitment to pushing the boundaries of technology. He highlighted the confluence of advancements in DNA sequencing, stem cell biology, and gene editing techniques, which now render a project of this magnitude feasible. Central to the mission is the restoration of balance to Tasmania’s fragile ecosystem. The Tasmanian Tiger, as the apex predator, played a crucial role in controlling population dynamics and curbing the spread of diseases among other species.

However, the endeavor goes beyond mere revival. Ben Lamm, founder and CEO of Colossal Biosciences, a key collaborator in the project, envisions a future where innovative gestational technologies and marsupial-focused Conservation efforts safeguard the resurrected species.

Colossal Biosciences is pioneering full-stage artificial wombs capable of nurturing embryos through ex-utero development, offering transformative possibilities for marsupial Conservation. Moreover, their research aims to address the challenges faced by species like the Tasmanian devil, whose limited maternal resources jeopardize offspring survival. The resurrection of the Tasmanian Tiger represents just one facet of Colossal’s broader mission, which extends to reviving other extinct species, including the woolly mammoth.

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